Understanding the risks of ZOLGENSMA
Elevated liver enzymes and liver injury
ZOLGENSMA could result in elevated liver enzymes and cause acute serious liver injury. An oral corticosteroid should be started the day before infusion with ZOLGENSMA. Your child’s doctor will monitor his or her liver function after treatment through blood tests and determine when to begin lowering the dose and eventually stopping the corticosteroid. You should contact your doctor immediately if your child’s skin and/or whites of the eyes appear yellowish, or if a dose of the corticosteroid is missed or vomited up.
Decreased levels of blood platelets may occur after treatment with ZOLGENSMA. Your doctor will monitor blood platelet levels through blood tests before and after treatment. Seek medical attention in the event of any unexpected bleeding or bruising.
You should talk with your doctor to decide if adjustments to the vaccination schedule should be made during corticosteroid use. Protection against respiratory syncytial virus (RSV) is recommended.
Viral respiratory infection before or after treatment with ZOLGENSMA infusion could lead to more serious complications. You should contact your doctor immediately if your child exhibits any of the following symptoms: coughing, wheezing, sneezing, runny nose, sore throat, or fever.